Total Organ Failure

Item from Plague Inc. by Ndemic Creations

The closer — the most lethal symptom in the game, evolved when it's time to stop spreading and start killing.

Also known as: TOF, Organ Failure, The Closer

What They Know

Highest lethality rating of any base-game symptom — evolving it is often the tipping point toward extinction
Requires multiple prerequisite symptoms to unlock — can't skip directly to endgame lethality
Dramatically spikes cure research speed due to extreme severity and lethality
Optimal timing is after global infection saturation — premature evolution risks killing hosts before full spread
Combined with Coma, creates a lethal combination that overwhelms medical systems

Connections

evolved_by — bacteria
evolved_by — virus

View full profile at Simulacra.Ink

Total Organ Failure

Item from Plague Inc. by Ndemic Creations

The closer — the most lethal symptom in the game, evolved when it's time to stop spreading and start killing.

Also known as: TOF, Organ Failure, The Closer

What They Know

Highest lethality rating of any base-game symptom — evolving it is often the tipping point toward extinction
Requires multiple prerequisite symptoms to unlock — can't skip directly to endgame lethality
Dramatically spikes cure research speed due to extreme severity and lethality
Optimal timing is after global infection saturation — premature evolution risks killing hosts before full spread
Combined with Coma, creates a lethal combination that overwhelms medical systems

Connections

evolved_by — bacteria
evolved_by — virus

View full profile at Simulacra.Ink